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天然化合物

カタログ番号	製品名	別名	ターゲット
T11566	HIV-1 integrase inhibitor		Others
	Hiv-1 integrase inhibitor is an effective anti-HIV drug.		Others
T11568	HIV-1 integrase inhibitor 4		Others
	HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 3.7 nM).		Others
T11567	HIV-1 integrase inhibitor 3		Others
	HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 2.7 nM).		Others
T11565	HIV-1 integrase inhibitor 7		Others
	HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor (IC50: 33.3 nM).		Others
T60742	HIV-1 integrase inhibitor 8		HIV Protease
	HIV-1 integrase inhibitor 8 is an inhibitor of HIV-1 integrase. Integration is a required step in HIV replication [1].		HIV Protease
T4182	Lavendustin B		Tyrosinase , transporter , HIV Protease
	Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).		Tyrosinase , transporter , HIV Protease
T4493	Bictegravir	GS-9883	HIV Protease
	Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase (IC50: 7.5 nM).		HIV Protease
T2239L	Raltegravir	MK-0518	HIV Protease , Integrase
	Raltegravir (MK-0518) is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV INFECTION.		HIV Protease , Integrase
T0753	Salicylanilide	WR10019,2-Hydroxybenzanilide	HIV Protease , Reverse Transcriptase
	Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.		HIV Protease , Reverse Transcriptase
T6420	BMS-707035		HIV Protease
	BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.		HIV Protease
T2332	Elvitegravir	GS-9137,EVG,D06677,JTK-303	HIV Protease
	Elvitegravir (JTK-303) is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and Cytochrome P450 2C9 Inducer.		HIV Protease
T6198	Dolutegravir	S/GSK1349572,GSK1349572	HIV Protease
	Dolutegravir (GSK1349572) (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.		HIV Protease
T2239	Raltegravir potassium	MK 0518 potassium salt,Raltegravir potassium salt	HIV Protease , Integrase
	Raltegravir potassium (MK 0518 potassium salt) salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.		HIV Protease , Integrase
T9854	HIV-1 inhibitor-6	3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-	HIV Protease
	HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibitor that blocks HIV replication.		HIV Protease
T2329	Dolutegravir sodium	GSK1349572,GSK-1349572A	HIV Protease
	Dolutegravir sodium (GSK-1349572A) salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.		HIV Protease
T62156	HIV-1 integrase inhibitor 9
	HIV-1 integrase inhibitor 9 (compound 8a) is a potent inhibitor of HIV-1 RNase H (IC50: 12.3 μM) and has antiviral effects.
T72162	HIV-1 integrase inhibitor 10
	HIV-1 Integrase Inhibitor 10, an orally active allosteric integrase inhibitor (ALLINI), effectively inhibits the NLRepRluc virus's viral outgrowth in MT-2 cells, exhibiting EC50 values of 3-5 nM. This compound is utilize...
T6098	Cabotegravir	GSK744,GSK-1265744,S/GSK1265744	HIV Protease
	Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).		HIV Protease
T15483	LEDGIN6	HIV-1 integrase inhibitor 2	Others
	HIV-1 integrase inhibitor 2 is used for the treatment of human immunodeficiency virus (HIV) infection.		Others
T6589	MK-2048	MK2048	HIV Protease , Integrase
	MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.		HIV Protease , Integrase
T35340	Bictegravir Sodium	GS-9883 Sodium	HIV Protease
	Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity		HIV Protease
T30479	Bis-T-23	Bis T-23,Bis-T 23,AG1717	HIV Protease
	Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV...		HIV Protease
T39755	Pirmitegravir	STP0404	HIV Protease
	Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant an...		HIV Protease
T11074	Dolutegravir intermediate-1	1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid	HIV Protease
	Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is a new synthetic Dolutegravir intermediate. Dolutegravir is an integrase inhibitor develope...		HIV Protease
T16829	(S)-BI-1001		HIV Protease
	(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).		HIV Protease
T19670	BMS-538203
	BMS-538203 is a novel HIV integrase inhibitor.
T24752	S-1360	GW810781,GW-810781,GSK-S-1360,S1360,S 1360
	S-1360 is an inhibitor of HIV-1 integrase.
T31125	CX14442
	Cx14442 sodium is a new effective HIV-1 integrase inhibitor.
T68414	5-ClTEP
	5-ClTEP is a HIV-1 integrase inhibitor.
T64096	Integrase-LEDGF/p75 allosteric inhibitor 1
	Integrase-LEDGF/p75 allosteric inhibitor 1 is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. It inhibits HIV-1 DNA integration and exhibits antiviral effects, acting on the HIV-1 recombinant mo...
T14559	BI 224436		HIV Protease
			HIV Protease
T24366	L 870810	L-870,810,L870810,L 870,810,L870,810,L-870810
	L 870810 is a small-molecule inhibitor of HIV-1 integrase with potent antiviral activity in cell culture and good pharmacokinetic properties.
T79021	GSK3839919A
	GSK3839919A is a potent allosteric inhibitor of HIV-1 integrase [1].
T73524	XZ426
	XZ426 is a potent integrase strand transfer inhibitor with anti- HIV activity .
T70791	GSK-1264
	GSK-1264 is an allosteric inhibitor of human immunodeficiency virus (HIV) integrase which blocks viral replication and abnormal multimerization involving specific protein domains.
T36793	Dolutegravir M1
	Dolutegravir M1 is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed primarily by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1. 1.Zhu, J., Wang, P., Li, F., et al.CYP1A1 and 1B1-mediated met...
T28811	SM111	SM 111,SM-111
	SM111 inhibits in vitro replication of HIV-1, including strains resistant to reverse transcriptase, licensed protease, and integrase inhibitors, without major cellular toxicity.
T62983	Raltegravir sodium
	Raltegravir (MK 0518) sodium is a potent, orally active HIV integrase (IN) inhibitor.
T71009	Dolutegravir SR Isomer
	Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripher...
T70881	Dolutegravir RR Isomer
	Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mono...
T68364	GS-9160
	GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since tre...
T36794	Dolutegravir O-β-D-Glucuronide
	Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized ...
T63977	GSK3739936
	GSK3739936 is a potent inhibitor of HIV-1 allosteric integrase (IC50: 11.1 nM, EC50: 1.7 nM). GSK3739936 is also a weak inhibitor of CYP with an IC50 >24.3 μM. It has good pharmacokinetic properties with rapid absorption...
T62328	Cabotegravir sodium
	Cabotegravir sodium is a potent inhibitor of HIV integrase and is able to act on HIVADA (IC50: 2.5 nM). cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1 and is less li...
T37713	Funalenone
	Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μ...

Compounds

HIV-1 integrase inhibitor

T11566

Synonym:

Target: Others

HIV-1 integrase inhibitor 4

T11568

Synonym:

Target: Others

HIV-1 integrase inhibitor 3

T11567

Synonym:

Target: Others

HIV-1 integrase inhibitor 7

T11565

Synonym:

Target: Others

HIV-1 integrase inhibitor 8

T60742

Synonym:

Target: HIV Protease

lavendustin B

T4182

Synonym:

Target: Tyrosinase, transporter, HIV Protease

Bictegravir

T4493

Synonym: GS-9883

Target: HIV Protease

Raltegravir

T2239L

Synonym: MK-0518

Target: HIV Protease, Integrase

Salicylanilide

T0753

Synonym: WR10019,2-Hydroxybenzanilide

Target: HIV Protease, Reverse Transcriptase

BMS-707035

T6420

Synonym:

Target: HIV Protease

Elvitegravir

T2332

Synonym: GS-9137,EVG,D06677,JTK-303

Target: HIV Protease

Dolutegravir

T6198

Synonym: S/GSK1349572,GSK1349572

Target: HIV Protease

Raltegravir potassium

T2239

Synonym: MK 0518 potassium salt,Raltegravir potassium salt

Target: HIV Protease, Integrase

HIV-1 inhibitor-6

T9854

Synonym: 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-

Target: HIV Protease

Dolutegravir sodium

T2329

Synonym: GSK1349572,GSK-1349572A

Target: HIV Protease

HIV-1 integrase inhibitor 9

T62156

Synonym:

Target:

HIV-1 integrase inhibitor 10

Synonym: GSK744,GSK-1265744,S/GSK1265744

Target: HIV Protease

LEDGIN6

T15483

Synonym: HIV-1 integrase inhibitor 2

Target: HIV Protease, Integrase

Bictegravir Sodium

T35340

Synonym: GS-9883 Sodium

Target: HIV Protease

Bis-T-23

T30479

Synonym: Bis T-23,Bis-T 23,AG1717

Target: HIV Protease

Pirmitegravir

T39755

Synonym: STP0404

Target: HIV Protease

Dolutegravir intermediate-1

T11074

Synonym: 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Target: HIV Protease

(S)-BI-1001

T16829

Synonym:

Target: HIV Protease

Synonym: GW810781,GW-810781,GSK-S-1360,S1360,S 1360

Integrase-LEDGF/p75 allosteric inhibitor 1

Target: HIV Protease

L 870810

T24366

Synonym: L-870,810,L870810,L 870,810,L870,810,L-870810

Synonym: SM 111,SM-111

Dolutegravir SR Isomer

T71009

Synonym:

Target:

Dolutegravir RR Isomer

Dolutegravir O-β-D-Glucuronide

カタログ番号	製品名	別名	ターゲット
T6S2391	L-Chicoric Acid	(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid	Others , HIV Protease
	L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ...		Others , HIV Protease
TN2158	Robinetin	3,3',4',5',7-Pentahydroxyflavone	Anti-infection , HIV Protease , Antibacterial
	Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency.		Anti-infection , HIV Protease , Antibacterial
TL0006	Cichoric Acid	Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species , HIV Protease
	Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and ...		Reactive Oxygen Species , HIV Protease
T4S1521	1,4-Dicaffeoylquinic acid		HIV Protease
	1,4-Dicaffeoylquinic acid has antioxidant activity.1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentration...		HIV Protease
T2S1158	4,5-Dicaffeoylquinic acid	3,4-Dicaffeoylquinic acid,Isochlorogenic acid C	Others , HBV , Endogenous Metabolite
	1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.		Others , HBV , Endogenous Metabolite
TN6518	4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol
	4,4-di(4-Hydroxy-3-methoxyphenly)-2,3-dimethylbutanol has antioxidant and potential cytotoxic abilities, it also shows inhibition against HIV-1 integrase.
T11219	Equisetin		Others
	Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence ...		Others
T79967	Dihydroobionin B
	Dihydroobionin B exhibits potent (please insert the rest of the sentence for revision).
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,...